| Farnesyl pyrophosphate | |
|---|---|
| Identifiers | |
| CAS number | 13058-04-3 |
| PubChem | 706 |
| MeSH | farnesyl+pyrophosphate |
| Properties | |
| Molecular formula | C15H28O7P2 |
| Molar mass | 382.326 |
| (verify) (what is: /?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
Farnesyl pyrophosphate (FPP), also known as farnesyl diphosphate (FDP), is an intermediate in the HMG-CoA reductase pathway used by organisms in the biosynthesis of terpenes, terpenoids, and sterols.
It is the immediate precursor of squalene (via the enzyme squalene synthase), dehydrodolichol diphosphate (a precursor of dolichol), and geranylgeranyl pyrophosphate (GGPP).
Farnesyl pyrophosphate synthase (a prenyl transferase) catalyzes sequential condensation reactions of dimethylallyl pyrophosphate with 2 units of 3-isopentenyl pyrophosphate to form farnesyl pyrophosphate, as is shown in the following two steps:
The above reactions are inhibited by bisphosphonates (used for osteoporosis).
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